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    Axon 3639

    CAS [2376297-69-5]

    MF C26H26N4O3S
    MW 474.57

    • Purity: 98%
    • Soluble in DMSO
    Recently added

    Description

    PTX80 is a first-in-class inhibitor of protein degradation by targeting the autophagy receptor p62/SQSTM1. PTX80 binds to p62, inducing a decrease in soluble p62 and formation of insoluble p62 aggregates, and failure of polyubiquitinated proteins to colocalize with p62. PTX80 induces proteotoxic stress and activation of unfolded protein response, which, in turn, leads to apoptosis.

    KEYWORDS: PTX80 | p62/SQSTM1 ligand | PTX 80 | PTX-80 | CAS [2376297-69-5] | [2376297-70-8] | [2376297-71-9] | Ubiquitin | Inhibitor | Proteins | Sequestosome 1 | UPR

    First-in-class inhibitor of protein degradation by targeting p62/SQSTM1

    Chemical name

    4,4'-(1E,1'E)-(1-(3-(Dimethylamino)propylsulfonyl)-4-oxopiperidine-3,5-diylidene)bis(methan-1-yl-1-ylidene)dibenzonitrile

    Parent CAS No.

    [2376297-69-5]

    Order
    Size Unit Price Stock
    5 mg $132.00 In Stock
    25 mg $462.00 In Stock
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    The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

    Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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