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    All cells in a multicellular organism are constantly exposed to a variety of extracellular signals that they need to interpret and translate into an appropriate response to their environment. These signals can be soluble factors generated locally (for example, synaptic transmission) or distantly (for example, hormones and growth factors), ligands on the surface of other cells, or the extracellular matrix itself. To achieve this, cells maintain a diversity of receptors on their surface that respond specifically to individual stimuli. These receptors fall into families, based primarily on the way in which they generate the intracellular signals that give rise to the particular functional responses. Moreover, the activity of a given receptor can be modulated by other signaling pathways in a variety of ways, generating the flexibility required of such a complex system.  Axon Ligands™ that target receptors are categorized based on the major classification proposed by the IUPAC, incluing G-protein coupled receptors (GPCRs), enzyme linked receptors,  nuclear receptors, sigma receptors, PAQR receptorscytokine receptors, and a number of unclassified receptors (including integrin, thrombopoietin, and nucleotide-binding oligomerization domain-like (NLR) receptors[1].


    [1] I.J. Uings, S.N. Farrow. Cell receptors and cell signaling. Mol. Pathol. 2000, 53, 295-299.

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    Axon ID Name Description From price
    1064 Prop-2-ynyl-2-aminotetraline hydrochloride Dopamine agonist Inquire
    2467 (+)-ITD-1 Selective inhibitor of TGFβ/Smad signaling that promotes cardiogenesis $181.50
    1107 (+)-MDL 105725 5-HT2A antagonist $143.00
    1073 (+)-PD 128907 hydrochloride D3 agonist $132.00
    1071 (+)-PHNO hydrochloride D2 agonist $121.00
    2239 (+)-ZK 216348 Selective nonsteroidal glucocorticoid receptor (GR) agonist $137.50
    1108 (-)-MDL 105725 5-HT2A antagonist Inquire
    1092 (-)-NPPCC 5-HT1A agonist Inquire
    1074 (-)-PD 128907 hydrochloride D3 agonist $148.50
    1359 (-)-WAY 100135 dihydrochloride 5-HT1A antagonist $104.50
    1049 (R)-(+)-5-methoxy-2-aminotetraline hydrochloride Dopamine agonist Inquire
    1013 (R)-(+)-7-Hydroxy-DPAT hydrobromide D3 agonist Inquire
    1016 (R)-(+)-8-Hydroxy-DPAT hydrobromide 5-HT1A agonist $115.50
    1058 (R)-(+)-8-Methoxy-2-aminotetraline hydrochloride Building Block; 5-HT1A agonist Inquire
    1714 (R)-(+)-SLV 319 Inactive enantiomer of SLV 319 $104.50
    1095 (R)-(-)-LY 426965 dihydrochloride 5-HT1A antagonist $126.50
    1007 (R)-5-Hydroxy-DPAT hydrobromide D2 antagonist $159.50
    1026 (R)-5-Methoxy-N-propyl-2-aminotetraline hydrochloride Dopamine agonist Inquire
    1010 (R)-6-Hydroxy-DPAT hydrobromide Dopamine agonist Inquire
    1997 (R)-6-Hydroxybuspirone hydrochloride 5-HT1A partial agonist $115.50
    1055 (R)-7-Methoxy-2-aminotetraline hydrochloride Dopamine agonist $137.50
    1036 (R)-PPHT hydrochloride (R)-enantiomer of PPHT (Axon 1035); D2 agonist Inquire
    1739 (RS)-3,5-DHPG mGluR1 and mGluR5 agonist (rac. Axon 1740) $88.00
    1050 (S)-(-)-5-methoxy-2-aminotetraline hydrochloride Dopamine agonist $159.50
    1014 (S)-(-)-7-Hydroxy-DPAT hydrochloride D3 agonist $126.50
    1017 (S)-(-)-8-Hydroxy-DPAT hydrobromide 5-HT1A agonist $126.50
    1059 (S)-(-)-8-methoxy-2-aminotetraline hydrochloride Building Block; 5-HT1A agonist Inquire
    1740 (S)-3,5-DHPG mGluR1 and mGluR5 agonist $88.00
    1008 (S)-5-Hydroxy-DPAT hydrobromide D2 agonist $159.50
    1027 (S)-5-Methoxy-N-propyl-2-aminotetraline hydrochloride Dopamine agonist Inquire

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