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    The signaling pathways controlling cell growth and differentiation are almost invariably altered in cancer. During the course of tumor progression, cancer cells acquire a number of characteristic alterations. These include the capacities to proliferate independently of exogenous growth-promoting or growth-inhibitory signals, to invade surrounding tissues and metastasize to distant sites, to elicit an angiogenic response, and to evade mechanisms that limit cell proliferation, such as apoptosis and replicative senescence. These properties reflect alterations in the cellular signaling pathways that in normal cells control cell proliferation, motility, and survival. These interconnected pathways are being deciphered, but understanding the alterations that lead to cancer and correcting them is a substantial challenge. Among the key pathways are those controlling cell proliferation, which coordinate a response to the cellular environment, with the mTOR kinase as a critical node. Tumour development is influenced by infections and inflammation, and the complex role of the nuclear factor-B transcription factors is being unravelled. Expansion of tumour cells depends on nutrient supply and vascularization, which is orchestrated by the transcription factor known as HIF. And the metastatic spread of primary tumours to other organs is facilitated by many signaling pathways[1],[2].

    Cell Signaling and Oncology products Library

    For your convenience, you can order a library of all of our Cell Signaling and Oncology research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (>800 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.

    Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.

       Axon 5051 - Cell signaling and Oncology Library.xls                   

     

    [1] A. Eccleston, R. Dhand. Signalling in cancer. Nature 441, 423, editorial note
    [2] G.S. Martin. Cell signaling and cancer. Cancer Cell. 2003 Sep;4(3):167-74.

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    Axon ID Name Description From price
    3144 (+)-Blebbistatin Negative control of (±)-Blebbistatin as an inhibitor of class II myosins $99.00
    2467 (+)-ITD-1 Selective inhibitor of TGFβ/Smad signaling that promotes cardiogenesis $181.50
    1989 (+)-JQ-1

    Potent and selective BET bromodomain inhibitor

    $77.00
    1730 (+)-Kifunensine α-mannosidase inhibitor $132.00
    2239 (+)-ZK 216348 Selective nonsteroidal glucocorticoid receptor (GR) agonist $137.50
    3074 (-)-Blebbistatin Selective inhibitor of class II myosins; Active enantiomer of (±)-Blebbistatin $99.00
    1758 (R)-(+)-BAY K 8644 Calcium (Ca2+) channel modulator $126.50
    1229 (R)-(-)-Rolipram PDE4 inhibitor $121.00
    2830 (R)-CE3F4 Potent inhibitor of EPAC1 $115.50
    1432 (S)-(+)-Rolipram PDE4 inhibitor $126.50
    1759 (S)-(-)-BAY K 8644 Calcium (Ca2+) channel activator (L-type voltage-gated) $126.50
    2296 (S)-Crizotinib MTH1 inhibitor $93.50
    3704 (S)-ErSO Inactive enantiomer of ErSO $198.00
    2221 (Z)-Endoxifen The more active (Z)-isomer of Endoxifen (SERM; Axon 2190) $165.00
    2718 (±)-Blebbistatin Potent and specific inhibitor of class II myosins $104.50
    1687 (±)-E-Homocamptothecin Potent topoisomerase I (Topo 1) inhibitor $132.00
    2537 1,5-Isoquinolinediol PARP1 inhibitor and neuroprotective agent $55.00
    2434 1-Deazaadenosine Adenosine deaminase (ADA) inhibitor with cytostatic activity in vitro $154.00
    1892 1-NM-PP1 Potent tyrosine kinase inhibitor (TKI) of multiple targets (Src, Fyn, Abl, CDK, Trk) $104.50
    2222 10058-F4 c-Myc inhibitor inducing cell-cycle arrest at G0/G1 phase $88.00
    3617 1R,3R-RSL3 (negative control) Negative control of 1S,3R-RSL3 as GPX4 inhibitor $99.00
    3611 1S,3R-RSL3 GPX4 inhibitor; Ferroptosis inducer $99.00
    2496 2,5-Dimethylcelecoxib Celecoxib analog with anti-tumor properties, lacking COX-2 inhibitory activity $82.50
    1496 3-Aminobenzamide Competitive small molecule inhibitor of PARP $44.00
    2175 3PO Inhibitor of HIF-1-induced PFKFB3, an enzyme with a key role in glycolysis. $71.50
    3189 4-CPPC First potent, selective and reversible inhibitor of MIF-2 $148.50
    2919 4-IBP Selective sigma-1 (σ-1) receptor agonist $99.00
    1902 4μ8C IRE1α inhibitor $115.50
    3419 5-Bromo-2’-deoxyuridine Thymidine analog; Labeling agent of cell proliferation $55.00
    3476 5-NIdR Potent inhibitor of translesion DNA synthesis (TLS) $132.00

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