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    The medical use of stem cells, cells with the ability to perpetuate themselves through self-renewal and to differentiate into a particular cell type through differentiation, is receiving extensive interest as they might regenerate damaged tissue under the right conditions[1]. This unique capacity could serve patients suffering from organ malfunction, cell deficiency, and/or neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease by replacing affected/deficient cells with healthy new cells[2].
    Stem cells are unspecialized cells with an extraordinary ability to self-renew, capable of differentiating into one or more specialized cell types. When called into action following an injury, a stem cell self-renews – undergoes cell division and gives rise to one daughter stem cell and one progenitor cell. A progenitor cell is an intermediate cell type formed before it achieves a fully differentiated state. It is regarded as committed to differentiating along a particular cellular developmental pathway of stem cells:

    Stem cell → Stem cell + Progenitor cell → Differentiated cell 

    Based on their origin, stem cells are categorized either as embryonic stem cells (ESCs) or as postnatal stem cells/somatic stem cells/adult stem cells (ASCs).  They are characterized as totipotent (can generate all types of cells including germ cells (ESCs), pluripotent (can generate all types of cells except cells of the embryonic membrane), multipotent (can differentiate into more than one mature cell (MSC)), self-renewable (can divide without differentiation and create everlasting supply), and malleable stem cells (MSCs have plasticity and can undergo differentiation.

    Among the types of differentiation are:

    • Direct differentiation: specific type of cell in a special niche developed in a multistep unidirectional pathway;
    • Transdifferentiation: direct conversion of one cell type to another different cell type;
    • Dedifferentiation: unipotent stem cell becoming a multipotent one;
    • Cell fusion: stem cell fusing with a somatic cell resulting in another lineage.[3]

    Stem cell products Library

    For your convenience, you can order a library of all of our Stem cell research related products. Make your personal library by cherry picking products of your interest from our comprehensive list (142 products), or order all together not to miss any. The libraries will be shipped as 10 mM solutions (in DMSO, 250 µL of each selected Axon Ligand™) on a 96-well microtiter plate with a clear map of its contents.

    Simply download our comprehensive list of epigenetics products below (Microsoft Excel (.xls)), check the products to be included, and return your list to order the library of your preference.

       Axon 5053 - Stem cell Library.xls                   


    The pharmacological tools in this category could interact in any way with the complex cell differentiating processes involved in the transformation of an un-programmed stem cell into its destination cell type. Examples of biological targets of significance in stem cell research are:

    Enzymes

     

     

    AMPK

    CDC42

    CHK

    CK

    DNA methyltransferase

    GSK-3

    HHAT

    HMTase

    JAK

    MEK

    MPS1 Kinase

    mTOR

    PI3K

    Porcupine

    Rac

    ROCK

    TNKS

    γ-Secretase

    Receptors

     

     

    BMP-ALK

    FGFR

    Smoothened (SMO)

    TGF-βR

     

     

    Ion Channels

     

     

    Ca Channel

     

     

    Signaling pathways

     

     

    Hedgehog

    TGF-β/SMAD

    Wnt/β-Catenin

    Transcription factors

     

     

    AHR

    STAT

     

    Proteins

     

     

    Aggrecan

    β-Catenin

     

    Related product categories: Stem cell differentiators, Stem cell inhibitor sets


    [1] Stem cells, cancer, and cancer stem cells. Tannishtha Reya, Sean J. Morrison, Michael F. Clarke, Irving L. Weissman. Nature, Vol 414, 2001, 105.
    [2] Embryonic stem cells in drug discovery. J. McNeish. Nature Rev. Drug Disc. 2004, 3, 70.
    [3] from: R.R. Nadig et al. Stem cell therapy - Hype or hope? A review. J. Conserv. Dent. 2009, 12, 131-138.

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    Axon ID Name Description From price
    2467 (+)-ITD-1 Selective inhibitor of TGFβ/Smad signaling that promotes cardiogenesis $181.50
    1758 (R)-(+)-BAY K 8644 Calcium (Ca2+) channel modulator $126.50
    1759 (S)-(-)-BAY K 8644 Calcium (Ca2+) channel activator (L-type voltage-gated) $126.50
    3419 5-Bromo-2’-deoxyuridine Thymidine analog; Labeling agent of cell proliferation $55.00
    1909 A 1070722 Selective inhibitor of GSK-3 $104.50
    1466 A 769662 AMPK activator $93.50
    1744 A 77-01 TGF-βR 1 inhibitor; ALK 5 inhibitor $88.00
    1421 A 83-01 TGF-βR 1 inhibitor; ALK 5 inhibitor $77.00
    2389 AICAR Potent AMPK activator and inducer of differentiation of NSCs $49.50
    2551 Alda 1 Small molecule activator of ALDH2 $71.50
    1738 AMD 3100 CXCR4 antagonist $93.50
    2167 AR-A 014418 ATP-competitive GSK-3 inhibitor $93.50
    1992 AS 1517499 Potent and selective STAT6 inhibitor $143.00
    2187 AS 1892802 Potent, selective, ATP-competitive ROCK inhibitor $104.50
    5051 Axon Ligands? Cell signaling and Oncology compound library Axon Ligands? Cell signaling and Oncology compound library Inquire
    5053 Axon Ligands? Stem cell compound library Axon Ligands? Stem cell compound library Inquire
    1642 AZ 3146 MPS1 kinase inhibitor $88.00
    2171 AZD 1080 Selective inhibitor of GSK-3α and GSK-3β $121.00
    2194 AZD 2858 hydrochloride Potent and highly selective Glycogen Synthase Kinase-3β inhibitor $104.50
    1516 AZD 6244 MEK1 and MEK2 inhibitor $66.00
    1399 AZD 7762 hydrochloride CHK inhibitor $66.00
    1561 AZD 8055 mTOR inhibitor $88.00
    3055 B591 Potent, specific class I PI3K inhibitor $137.50
    1697 BAY K 8644 Calcium (Ca2+) channel activator (L-type voltage-gated) $104.50
    2117 Begacestat Selective γ-secretase inhibitor (GSI) $93.50
    1528 BI-D1870 RSK inhibitor (p90 RSK specific) $88.00
    1693 BIO GSK-3 inhibitor $104.50
    1692 BIX 01294 trihydrochloride HMTase inhibitor (G9a and G9a-like protein) $88.00
    1809 BIX 02189 MEK5 inhibitor; ERK5 inhibitor $121.00
    3346 BIX02188 Potent MEK5 inhibitor $121.00

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