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    Transcription factors (TFs) are key cellular components that control the first step of gene expression, the transcription of DNA into RNA sequences. By ensuring the correct expression of specific genes, the transcriptional regulatory system plays a central part in controlling many biological processes, ranging from cell cycle progression and maintenance of intracellular metabolic and physiological balance, to cellular differentiation and developmental time courses. TFs may be constitutively active or conditionally active. The most common classification of TFs is based on the structure of their DNA-binding domains. Grouping TFs by structural domain has been extremely useful in uncovering how they recognize and bind specific DNA sequences, as well as providing insights into their evolutionary histories. Moreover, in some instances the DNA-binding domain provides clues to their function[1]. A comprehensive classification recognizes four superfamilies with well-defined structural homology: basic domains TFs (1), Zinc-coordinating domains TFs (2), helix-turn-helix (HTH) domains TFs (3), and beta-scaffold domains with Minor Groove Contacts TFs (4). Additionally, a fifth family of orphan TFs exists for which no superclass assignment can be done yet because of lack of structural information[2].


    [1] J.M. Vaquerizas et al. A census of human transcription factors: function, expression and evolution. Nat. Rev. Genetics 2009, 10, 252-263.
    [2] P. Stegmaier, A.E. Kel, E. Wingender. SystematicDNA-binding domain classification of transcription factors. Genome Inform. 2004, 15, 276-286.

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    Axon ID Name Description From price
    2222 10058-F4 c-Myc inhibitor inducing cell-cycle arrest at G0/G1 phase $88.00
    1992 AS 1517499 Potent and selective STAT6 inhibitor $143.00
    2839 AS 1842856 Inhibitor of the Forkhead box protein O1 (FOXO1) $104.50
    3760 Belzutifan Second-generation potent, selective and orally active HIF-2α inhibitor  Recently added $308.00
    3361 BI-3802 Highly potent and efficacious BCL6 degrader $143.00
    2489 Brassinin Dual IDO1/STAT3 inhibitor with antifungal and anticancer activity $82.50
    3394 CADD522 Potent inhibitor of RUNX2-DNA binding $99.00
    2699 CCT251236 HSF1 stress pathway inhibitor $159.50
    1863 CID 5951923 Inhibitor of Krüppel-like factor 5 (KLF5) $148.50
    3224 CLK8 CLOCK/BMAL1 interaction inhibitor $176.00
    3035 Compound 10

    Tool compound targeting the NFAT:AP-1 transcriptional complex on DNA.

    $165.00
    2841 COTI-2 Reactivator of mutant p53 $137.50
    2879 CP 31398 Stabilizer of p53 and inducer of apoptosis $104.50
    3518 DCZ0805 NF-κB activation inhibitor $143.00
    1935 DiMNF Selective aryl hydrocarbon receptor modulator (SAhRM) $115.50
    3412 DTHIB Direct and selective HSF1 inhibitor $99.00
    2080 EVP 4593 NF-κB activation inhibitor; inhibits SOC pathway $121.00
    2975 Fatostatin hydrobromide Specific inhibitor of SREBP cleavage-activating protein (SCAP) $99.00
    2384 FDI 6 Inhibitor of the Forkhead box protein M1 (FOXM1) $108.90
    3457 Fludarabine Inhibitor of DNA synthesis; STAT-1 activation inhibitor $55.00
    2959 FM19G11 Potent HIFα inhibitor $104.50
    2157 FQI 1 Inhibitor of α-globin transcription factor CP2 (LSF) $104.50
    2642 GANT61 Inhibitor of GLI-mediated transcription and Hedgehog (Hh) signaling $132.00
    2034 HIF-2 inhibitor 2 Allosteric inhibitor of HIF-2 $104.50
    2614 HIF-2a Translation Inhibitor 76 HIF-2a translation inhibitor that works independent of mTOR $77.00
    1890 HSF1A Human HSF1 activator $137.50
    2101 HSF1B Human HSF1 activator $137.50
    2349 JSH 23 Inhibitor of NF-κB transcription and nuclear translocation of p65 without affecting IκBα degradation $104.50
    2378 Kartogenin Promotor of chondrocyte differentiation from primary human MSCs $82.50
    2538 KRIBB11 HSF1 inhibitor that blocks the induction of HSP27 and HSP70 $137.50

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